200711-22-4 Usage
Description
6-(trifluoromethyl)-5-methylindoline is a chemical compound with the molecular formula C11H9F3N. It is an indoline derivative that contains a trifluoromethyl group and a methyl group attached to the indoline ring. 6-(trifluoromethyl)-5-methylindoline has unique structural features and chemical properties, making it a promising candidate for various applications in organic synthesis, medicinal chemistry, and material science.
Uses
Used in Organic Synthesis:
6-(trifluoromethyl)-5-methylindoline is used as a building block in the synthesis of pharmaceuticals, agrochemicals, and functional materials. Its unique structural features and chemical properties make it a valuable component in the development of new organic compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 6-(trifluoromethyl)-5-methylindoline is used as a key intermediate in the synthesis of potential drug candidates. Its trifluoromethyl group can impart desirable properties such as increased lipophilicity and metabolic stability, enhancing the compound's pharmacokinetic and pharmacodynamic properties.
Used in Material Science:
6-(trifluoromethyl)-5-methylindoline is also used in material science for the development of functional materials with specific properties. Its unique structure and chemical properties can contribute to the creation of advanced materials for various applications.
Researchers continue to explore the potential uses and biological activities of 6-(trifluoromethyl)-5-methylindoline in various fields, aiming to unlock its full potential and contribute to the advancement of science and technology.
Check Digit Verification of cas no
The CAS Registry Mumber 200711-22-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,0,7,1 and 1 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 200711-22:
(8*2)+(7*0)+(6*0)+(5*7)+(4*1)+(3*1)+(2*2)+(1*2)=64
64 % 10 = 4
So 200711-22-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H10F3N/c1-6-4-7-2-3-14-9(7)5-8(6)10(11,12)13/h4-5,14H,2-3H2,1H3
200711-22-4Relevant articles and documents
Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: Identification of 5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent
Bromidge, Steven M.,Dabbs, Steven,Davies, David T.,Davies, Susannah,Duckworth, D. Malcolm,Forbes, Ian T.,Gaster, Laramie M.,Ham, Peter,Jones, Graham E.,King, Frank D.,Mulholland, Keith R.,Saunders, Damian V.,Wyman, Paul A.,Blaney, Frank E.,Clarke, Stephen E.,Blackburn, Thomas P.,Holland, Vicky,Kennett, Guy A.,Lightowler, Sean,Middlemiss, Derek N.,Trail, Brenda,Riley, Graham J.,Wood, Martyn D.
, p. 1123 - 1134 (2007/10/03)
The evolution, synthesis, and biological activity of a novel series of 5-HT(2C) receptor inverse agonists are reported. Biarylcarbamoylindolines have been identified with excellent 5-HT(2C) affinity and selectivity over 5- HT(2A) receptors. In addition, (pyridyloxypyridyl)carbamoylindolines have been discovered with additional selectivity over the closely related 5-HT(2B) receptor. Compounds from this series are inverse agonists at the human cloned 5-HT(2C) receptor, completely abolishing basal activity in a functional assay. The new series have reduced P450 inhibitory liability compared to a previously described series of 1-(3-pyridylcarbamoyl)indolines (Bromidge et al. J. Med. Chem. 1998, 41, 1598) from which they evolved. Compounds from this series showed excellent oral activity in a rat mCPP hypolocomotion model and in animal models of anxiety. On the basis of their favorable biological profile, 32 (SB-228357) and 40 (SB-243213) have been selected for further evaluation to determine their therapeutic potential for the treatment of CNS disorders such as depression and anxiety.
