200712-67-0Relevant academic research and scientific papers
First synthetic carbohydrates with the full anticoagulant properties of heparin
Petitou, Maurice,Duchaussoy, Philippe,Driguez, Pierre-A.,Jaurand, Guy,Herault, Jean-P.,Lormeau, Jean-C.,Van Boeckel, Constant A.A.,Herbert, Jean-M.
, p. 3009 - 3014 (1998)
A single disaccharide building block is required to obtain synthetic carbohydrates that reproduce the anticoagulant activity of heparin and inhibit thrombin (n > 6) and/or factor Xa (n ≥ 2; see reaction scheme). Thus, there is evidence that heparin fragme
Identification of a hexasaccharide sequence able to inhibit thrombin and suitable for 'polymerisation'
Duchaussoy, Philippe,Jaurand, Guy,Driguez, Pierre-A.,Lederman, Isidore,Gourvenec, Francoise,Strassel, Jean-M.,Sizun, Philippe,Petitou, Maurice,Herbert, Jean-M.
, p. 63 - 84 (2007/10/03)
Three hexasaccharides, having from low to very high affinity for antithrombin, were synthesised from disaccharide building block precursors. One of them, methyl(sodium 2,3-di-O-methyl-4-O-sodium sulfonato-α-L-idopyranosyluronate)-(1→4)-[(2,3,6-tri-O-sodium sulfonato-α-D-glucopyranosyl)-(1→4)-(sodium 2,3-di-O-methyl-α-L-idopyranosyluronate)-(1→4)]2-2,3,6-tri-O-sodium sulfonato-α-D-glucopyranoside, obtainable from a single disaccharide building block precursor, constitutes a good starting point for obtaining simple oligosaccharidic heparin mimetics able to inhibit the two coagulation factors thrombin and Factor Xa. Copyright (C) 1999 Elsevier Science Ltd.
