200720-82-7Relevant academic research and scientific papers
Enantioselective synthesis of β-substituted butyric acid derivatives via orthoester Claisen rearrangement of enzymatically resolved allylic alcohols: Application to the synthesis of (R)-(-)-baclofen
Brenna, Elisabetta,Caraccia, Nicola,Fuganti, Claudio,Fuganti, Daniela,Grasselli, Piero
, p. 3801 - 3805 (1997)
A three step synthesis of (R)-(-)-baclofen is described. The key step is the orthoester Claisen rearrangement of enantiopure allylic alcohol (S,E)-(-)-1a, affording γ,δ-unsaturated ester (S,E)-(+)-6 with high stereoselectivity. This latter derivative is converted into (R)-(-)-baclofen through a high yield one-pot reaction.
