20073-22-7Relevant academic research and scientific papers
Condensation of salicylaldehydes with ethyl 4,4,4-trichloro-3-oxobutanoate: A facile approach for the synthesis of substituted 2H-chromene-3-carboxylates
Sairam, Mudulkar,Saidachary, Gannerla,Raju, Bhimapaka China
supporting information, p. 1338 - 1343 (2015/03/04)
A highly efficient and simple protocol has been developed for the preparation of ethyl 2-oxo-2H-chromene-3-carboxylates 3a-v by the condensation of salicylaldehydes 1a-v with ethyl 4,4,4-trichloro-3-oxobutanoate 2 for the first time. The reaction is proceeding via Knoevenagel pathway followed by a selective addition of the phenolic hydroxyl group to the carbonyl group adjacent to the CCl3 group rather than ester carbonyl due to a strong electron withdrawing effect and produced coumarin derivative 3a with the elimination of CHCl3.
A NEW PHOTOPRODUCT FROM FUROCOUMARIN PHOTOLYSIS IN DILUTE AQUEOUS SOLUTION: 5-FORMYL-6-HYDROXYBENZOFURAN
Marley, Karen A.,Larson, Richard A.
, p. 503 - 505 (2007/10/02)
This paper presents the analysis and identification of an unstable product previously undescribed from furocoumarin photolysis, 5-formyl-6-hydroxybenzofuran. Reverse-phase chromatography and solid-phase extraction techniques allowed its isolation.
