20074-78-6Relevant articles and documents
Mild and high-yielding molybdenum(VI) dichloride dioxide-catalyzed formation of Mono-, Di-, Tri-, and tetracarbamates from alcohols and aromatic or aliphatic isocyanates
Stock, Christian,Brueckner, Reinhard
, p. 2309 - 2330 (2012/11/07)
Both molybdenum(VI) dichloride dioxide (MoO2Cl2) and its dimethylformamide (DMF) complex catalyze the addition of alcohols to isocyanates giving carbamates. Most additions proceeded to completion at room temperature within 20 min using as little as 0.1 mol% of the catalyst when working on a 1-mmol scale or just 100 ppm working on a 20-mmol scale. Sterically encumbered substrates reacted to completion when 1 mol% of the catalyst was employed. Diols, triols, and tetraols reacted with monoisocyanates likewise, as did monofunctional alcohols and diisocyanates. These pairings furnished di-, tri-, tetra-, and dicarbamates, respectively. Reactants, which were poorly soluble in CH2Cl2 at room temperature required elevating the temperature and possibly choosing a higher-boiling solvent (ClCH 2CH2Cl, DMF) as well. Additions of diols to diisocyanates were feasible, too, giving polycarbamates as we presume. Copyright
3-(piperid-4-yl)-1,2-benzisoxazole and 3-(piperazin-4-yl)-1,2-benzisoxazole compounds
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, (2008/06/13)
Compounds of formula: STR1 wherein: A, m, n, E and Y are as defined in the description, the optical isomers thereof and the physiologically-tolerable salts thereof. These compounds, their optical isomers and their physiologically-tolerable salts, can be u
