2007919-81-3Relevant academic research and scientific papers
Identification of false positives in hTS hits to lead : The application of Bayesian models in HTS triage to rapidly deliver a series of selective TRPV4 antagonists
Skerratt, Sarah E.,Mills, James E. J.,Mistry, Jayesh
, p. 244 - 251 (2013/03/14)
Herein, we describe the discovery and optimisation of a series of potent and selective TRPV4 antagonists. The application of a variety of computational techniques (including Bayesian modelling) at the HTS triage stage enabled the early deprioritisation of likely frequent hitters. The use of methods to positively prioritise compounds for follow-up screening allowed the rapid identification of a number of interesting TRPV4 antagonist series. The hit-to-lead efforts in one such series, the hydroxypiperidines, will be described. The Royal Society of Chemistry 2013.
