20084-99-5Relevant articles and documents
Method for preparing alpha-cyperone derivatives
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Paragraph 0012-0013, (2017/08/27)
The invention discloses a method for preparing alpha-cyperone derivatives. The method comprises the steps: taking alpha-cyperone extracted from a traditional Chinese medicine cyperus rotundus as a raw material, reducing by sodium borohydride to obtain (4aS,7R)-1,4a-dimethyl-7-prop-1-en-2-yl-3,4,5,6,7,8-hexahydronaphthalene-2-alcohol, and carrying out a kinetic resolution reaction catalyzed by enzymes to obtain (2R,4aS,7R)-1,4a-dimethyl-7-prop-1-en-2-yl-3,4,5,6,7,8-hexahydronaphthalene-2-alcohol and (2S,4aS,7R)-1,4a-dimethyl-7-prop-1-en-2-yl-3,4,5,6,7,8-hexahydronaphthalene-2-alcohol. Prochiral ketone in alpha-cyperone is further basically turned into a chiral center, and resolution is further carried out; the method has the characteristics of simple operation, high product yield, good optical purity and the like.
Enzymic Resolution of (+/-)-Unsaturated Cyclic Terpene Alcohols via Asymmetric Hydrolysis of Corresponding Acetates by Microorganisms
Oritani, Takayuki,Yamashita, Kyohei
, p. 2637 - 2642 (2007/10/02)
Asymmetric hydrolysis of the acetates of (+/-)-cis and trans-carveols by microorganisms or their esterase produced chiral cis and trans-carveols and the acetates of their enantiomers.The enantioselectivity of the microbial hydrolysis and the optical purities of the products varied with the species of microorganisms.This method was also applied in separation of diastereomeric mixtures of (-)-carveols and (-)-7-epi-α-cyperols.