200878-51-9Relevant academic research and scientific papers
Vanadium-catalyzed regioselective oxidative coupling of 2-hydroxycarbazoles
Liu, Lei,Carroll, Patrick J.,Kozlowski, Marisa C.
, p. 508 - 511 (2015/03/05)
The first regioselective oxidative coupling of 2-hydroxycarbazoles is described. With a vanadium catalyst and oxygen as the terminal oxidant, dimers with an ortho-orthoa?2 coupling pattern were obtained with high selectivity. Further oxidation led to orthoa?2-orthoa?2 coupling to generate a tetramer, which provided insight that the atropisomerization barriers of the unsymmetrical biaryl bonds are much lower than expected.
Anti-Pneumocystis carinii pneumonia activity of dicationic carbazoles
Patrick,Boykin,Wilson,Tanious,Spychala,Bender,Hall,Dykstra,Ohemeng,Tidwell
, p. 781 - 793 (2007/10/03)
A series of 2,7- and 3,6-bis cationic carbazoles was synthesized and evaluated for activity against a rat model of Pneumocystis carinii pneumonia (PCP). The compounds were also tested for inhibition of topoisomerase II and binding to DNA. Several of the compounds proved to be more potent and less toxic than a standard anti-PCP drug (pentamidine). While no quantitative correlation was seen between anti-PCP activity, topoisomerase inhibition and DNA binding, a minimal level of DNA binding was found to be necessary for antimicrobial activity.
