200941-15-7

Upstream product

• 34123-66-5 O-isopropylisovanillin 
• 621-59-0 isovanillin 

Downstream Products

• 69048-73-3 5-hydroxy-2-iodo-4-methoxybenzaldehyde 
• 215715-44-9 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxybenzaldehyde 
• 363134-18-3 5-isopropoxy-4-methoxy-2-trimethylsilanylethynyl-benzaldehyde 
• 1072709-68-2 (E)-2'-cyclohexyl-5'-hydroxy-4'-methoxyacetophenone O-4-nitrobenzyl oxime 
• 1072708-52-1 (E)-5'-hydroxy-2'-iodo-4'-methoxypropiophenone O-4-nitrobenzyl oxime 
• 1072708-45-2 (E)-5'-hydroxy-2'-iodo-4'-methoxyacetophenone O-4-nitrobenzyl oxime 
• 1072708-47-4 (Z)-5'-hydroxy-2'-iodo-4'-methoxyacetophenone O-4-nitrobenzyl oxime 
• 1072708-42-9 (E)-3'-hydroxy-4'-methoxyacetophenone O-4-nitrobenzyl oxime 
• 1072709-23-9 (E)-2'-(4-trifluoromethoxyphenyl)-5'-hydroxy-4'-methoxyacetophenone O-4-nitrobenzyl oxime 
• 1072709-29-5 (E)-2'-(4-trifluoromethylphenyl)-5'-hydroxy-4'-methoxyacetophenone O-4-nitrobenzyl oxime 
• 1072709-25-1 (E)-2'-(4-fluorophenyl)-5'-hydroxy-4'-methoxyacetophenone O-4-nitrobenzyl oxime 
• 1072709-27-3 (E)-5'-hydroxy-4'-methoxy-2'-(4-methylphenyl)acetophenone O-4-nitrobenzyloxime 
• 1072709-19-3 (E)-2'-(4-chlorophenyl)-5'-hydroxy-4'-methoxyacetophenone O-4-nitrobenzyloxime 
• 1072709-11-5 (E)-5'-hydroxy-4'-methoxy-2'-phenylacetophenone O-4-nitrobenzyl oxime 

Relevant academic research and scientific papers

NON-STEROIDAL COMPOUNDS

The present invention relates to non-steroidal compounds useful in the treatment of inflammatory conditions and pharmaceutical compositions comprising them. A representative example of these compounds is formula (III).

Preparation of fused polycyclic alkaloids by ring closure of azomethine ylides, novel compounds thereof and their use as chemotherapeutic agents

A method for the preparation of a compound of general Formula: or pharmaceutically acceptable derivatives and salts, racemates, isomers and/or tautomers thereof comprising cyclizing an azomethine ylide of general Formula: wherein, A is a cyclic or non-cyc

Total synthesis and evaluation of lamellarin α 20-Sulfate analogues

In order to explore the influence of sulfate groups on the bioactivity profiles of marine alkaloids of the lamellarin class, three such alkaloids, lamellarin α lamellarin α 13,20-disulfate and H, were synthesized and their activities against HIV-1 integrase and cancer cell ines were compared with those of lamellarin α 20-sulfate, which is a selective inhibitor of HIV-1 integrase. Lamellarin α does not inhibit HIV-1 integrase but shows moderate cytotoxicity with good cell line selectivity. Lamellarin α13,20-disulfate is a moderate inhibitor of both HIV-1 integrase and cancer cell lines. Lamellarin H is a more potent inhibitor of HIV-1 integrase but lacked the specificity required to be medicinally useful. Copyright

Syntheses of lamellarins I and K by [3+2] cycloaddition of a nitrone to an alkyne

Lamellarins I and K were obtained by a new approach based on the 1,3-dipolar cycloaddition of a nitrone to an alkyne. The key cycloaddition yields an isoxazoline which rearranges to afford the central pyrrole ring.

Synthesis, X-Ray Crystal Structure and Tubulin-Binding Properties of a Benzofuran Analogue of the Potent Cytotoxic Agent Combretastatin A4

The benzofuran (4), a ring-fused analogue of the potent antimitotic agent combretastatin A4 (1), has been prepared by a convergent route involving 5-endo-dig iodocyclization of o-hydroxytolan (5) as the key step. Compound (4), which has been characterized crystallographically as well as spectroscopically, is inactive as a tubulin-binding agent.

Convergent total synthesis of lamellarin K

The azomethine ylide derived from dihydroisoquinolinium salt 24 undergoes an intramolecular [3 + 2] cycloaddition reaction to give pyrrole 25 which upon de-isopropylation affords the marine alkaloid lamellarin K 4.