20099-30-3

Upstream product

• 115-22-0 3-Hydroxy-3-methyl-2-butanone 
• 89-98-5 2-chloro-benzaldehyde 
• 5950-19-6 3-chloro-3-methyl-2-butanone 

Downstream Products

• 1220114-37-3 1-(2-chloro-phenyl)-4-hydroxy-1-(1H-indol-3-yl)-4-methyl-pentan-3-one 
• 111277-08-8 5-(2-Chloro-phenyl)-2,2-dimethyl-furan-3-one 
• 111277-16-8 1,2-Dibromo-1-(2-chloro-phenyl)-4-hydroxy-4-methyl-pentan-3-one 

Relevant academic research and scientific papers

Novel Type of the Favorskii Rearrangement Combined with Aldol Reaction Leading to γ-Butyrolactone Derivatives

Reaction of aromatic aldehydes or hetero-aromatic aldehydes with 3-chloro-3-methyl-2-butanone in ethanolic KOH at room temperature gave 3,3-dimethyl-5-aryltetrahydro-2-furanone as a major product.The reaction can be tentatively explained by the combination of Favorskii rearrangement and aldol reaction.

A Novel and Practical Synthetic Method of 3(2H)-Furanone Derivatives

A novel convenient synthetic method of 5-aryl-2,2-dimethyl-3(2H)-furanones (aryl = C6H5, 2-CH3C6H4, 3-CH3C6H4, 4-CH3C6H4, 2-ClC6H4, 4-ClC6H4, 2,4-Cl2C6H3) is described.It involves the Claisen-Schmidt condensation (potassium hydroxide/ethanol) of aromatic