20100-21-4Relevant academic research and scientific papers
A novel synthesis of 2-arylbenzimidazoles in molecular sieves-MeOH system and their antitubercular activity
Chaturvedi, Amit K.,Verma, Amit Kumar,Thakur, Jay Prakash,Roy, Sudeep,Bhushan Tripathi, Shashi,Kumar, Balagani Sathish,Khwaja, Sadiya,Sachan, Naresh K.,Sharma, Ashok,Chanda, Debabrata,Shanker, Karuna,Saikia, Dharmendra,Negi, Arvind S.
, p. 4551 - 4559 (2018/08/11)
Arylbenzimidazoles have been synthesized as antimycobacterial agents. An efficient synthesis has been developed for 2-arylbenzimidazoles from o-phenylenediamines and aromatic aldehydes in molecular sieves-methanol system. The methodology is straightforward to get 2-arylbenzimidazoles (3a–3z) in excellent yields with high chemoselectivity over 2-aryl-1-benzylbenzimidazoles (4a–4z). All these benzimidazole analogues were evaluated against M. tuberculosis in BACTEC radiometric assay. The compounds 4y and 4z exhibited potential antitubercular activity against M. tuberculosis H37RV, MIC at 16 μM and 24 μM respectively. The best compound of the series i.e. compound 4y was well tolerated by Swiss-albino mice in acute oral toxicity. Compound 4y possessing a diarylbenzimidazole core, can further be optimized for better activity.
A simple and straightforward synthesis of substituted 2-arylbenzimidazoles over silica gel
Chaturvedi, Amit K.,Negi, Arvind S.,Khare, Puja
, p. 4500 - 4504 (2013/04/24)
A solid phase strategy for the synthesis of substituted 2-arylbenzimidazoles over silica gel has been achieved starting from their corresponding o-phenylenediamines 1 and aromatic aldehydes 2. The reaction is very simple, convenient and straightforward, a
