201021-72-9

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 
• 1589-82-8 phenylmagnesium bromide 
• 103130-93-4 3-benzylcyclohex-2-en-1-one 

Downstream Products

• 223442-18-0 C₁₅H₁₆Cl₃NO 
• 201021-73-0 C₂₁H₂₄O₂S 

Relevant academic research and scientific papers

Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists

A novel series of spirobenzazepines was synthesized and evaluated for V1a and V2 receptor antagonist activity. Compounds 8b, 8i, and 8k have shown selective V1a receptor antagonist activity. Compounds 8p and 8q were shown to be dual V1a/V2 receptor antagonists.

CYCLOPENTENE DERIVATIVES USEFUL AS ANTAGONISTS OF THE MOTILIN RECEPTOR

The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor disorders. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.

Chemo-enzymatic preparation of optically active endo- bicyclo[4.1.0]heptan-2-ols

Resolutions of endo-bicyclo[4.1.O]heptan-2-ols were achieved by acylation in the presence of lipase from Candida antarctica (Novozym). The (1S,2R,6R) enantiomers reacted faster and the enantiomeric ratios were between 60 and 800 for the 6-substituted bicycloalkanols.