201030-32-2Relevant academic research and scientific papers
Correlation between optical rotation sign and conformation of γ- butyrolactones. An empirical correlation rule to predict optical activity and stereochemistry of γ-butyrolactones
Kang, Fu-An,Yin, Cheng-Lie
, p. 13155 - 13166 (1998)
A series of trans-4,5-disubstituted-γ-butyrolactones are found to adopt different conformations by 1H NMR spectroscopy, whose optical rotation signs are found to depend on the conformations they assume. An empirical correlation rule is proposed for the prediction of optical activity and stereochemistry of γ-butyrolactones, which is confirmed by the X-ray analyses of (+)- and (-)-γ-butyrolactones.
