201049-37-8

Basic information

• Product Name: epothilone E
• Synonyms: epothilone E;[4S,7R,8S,9S,13R,14S,16S(E)]-13,14-Epoxy-4,8-dihydroxy-5,5,7,9-tetramethyl-16-[2-[2-(hydroxymethyl)thiazol-4-yl]-1-methylvinyl]-1-oxacyclohexadecane-2,6-dione
• CAS NO: 201049-37-8
• Molecular Formula: C26H39NO7S
• Molecular Weight: 509.65536
• Mol File: 201049-37-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: epothilone E(CAS DataBase Reference)
• NIST Chemistry Reference: epothilone E(201049-37-8)
• EPA Substance Registry System: epothilone E(201049-37-8)

Safety Data

• Hazardous Substances Data: 201049-37-8(Hazardous Substances Data)

Usage

Uses

Epothilone E is a related compound of Epothilones, which are a novel class of antineoplastic agents with antitubulin activity. In addition, Epothilones utilize a similar mechanism of action to that of taxanes and are less susceptible to multidrug resistance caused by P-glycoprotein. Studies showed that Epothilones exhibit antitumor activity against human cancer cells that are taxane-resistant.

Upstream product

• 152044-53-6 epithilone A 
• 212321-22-7 4-((E)-2-((1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12-tetramethyl-5,9-dioxo-4,17-dioxabicyclo[14.1.0]heptadecan-3-yl)prop-1-en-1-yl)-2-methylthiazole 3-oxide 
• 152044-54-7 epothilone B 
• 212321-23-8 (4-((E)-2-((1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12-tetramethyl-5,9-dioxo-4,17-dioxabicyclo[14.1.0]-heptadecan-3-yl)prop-1-en-1-yl)thiazol-2-yl)methyl acetate 
• 204513-26-8 (Z)-(4S,7R,8S,9S,16S)-4-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-16-((E)-2-iodo-1-methyl-vinyl)-5,5,7,9-tetramethyl-oxacyclohexadec-13-ene-2,6-dione 
• 204513-24-6 (3S,6R,7S,8S)-3-(tert-Butyl-dimethyl-silanyloxy)-7-hydroxy-4,4,6,8-tetramethyl-5-oxo-tridec-12-enoic acid (S)-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester 
• 204513-16-6 (Z)-(4S,7R,8S,9S,16S)-4,8-Dihydroxy-16-((E)-2-iodo-1-methyl-vinyl)-5,5,7,9-tetramethyl-oxacyclohexadec-13-ene-2,6-dione 
• 204513-22-4 (3S,1E)-1-iodo-2-methylhexa-1,5-dien-3-ol 
• 204513-12-2 Desoxyepothilone E 

Relevant articles and documents

Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin

Photoaffinity labeling with an epothilone A photoprobe led to the identification of the β-tubulin peptides TARGSQQY and TSRGSQQY as targets of the photoprobe for polymerized tubulin. These peptides represent residues 274-281 in different β-tubulin isotype

Epothilones with modified side chain

Epothilones with a modified side chain and process for the preparation thereof are disclosed.

Total Synthesis of Epothilone E and Analogues with Modified Side Chains through the Stille Coupling Reaction

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