20105-69-5 Usage
Uses
Used in Anticancer Applications:
1-(2-deoxypentofuranuronosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione is used as an anti-cancer agent for its potential to inhibit DNA synthesis and repair, as well as induce cell death in cancer cells. It is particularly promising in the treatment of various forms of cancer due to its mechanism of action, which involves incorporation into DNA during replication, causing DNA damage and preventing cancer cells from dividing and growing.
Used in Pharmaceutical Research:
1-(2-deoxypentofuranuronosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione is used as a subject of research in the pharmaceutical industry for its potential as a treatment for various forms of cancer. Ongoing research aims to further explore the compound's properties and optimize its therapeutic potential.
Used in Drug Development:
1-(2-deoxypentofuranuronosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione is used as a candidate in drug development for cancer treatment. Its unique mechanism of action and potential to induce cell death in cancer cells make it a valuable compound for the development of new anti-cancer drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 20105-69-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,1,0 and 5 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 20105-69:
(7*2)+(6*0)+(5*1)+(4*0)+(3*5)+(2*6)+(1*9)=55
55 % 10 = 5
So 20105-69-5 is a valid CAS Registry Number.
20105-69-5Relevant academic research and scientific papers
Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates
Mackman, Richard L.,Boojamra, Constantine G.,Prasad, Vidya,Zhang, Lijun,Lin, Kuei-Ying,Petrakovsky, Oleg,Babusis, Darius,Chen, James,Douglas, Janet,Grant, Deborah,Hui, Hon C.,Kim, Choung U.,Markevitch, David Y.,Vela, Jennifer,Ray, Adrian,Cihlar, Tomas
, p. 6785 - 6789 (2008/09/18)
A series of nucleoside phosphonate reverse transcriptase (RT) inhibitors have been synthesized and their anti-HIV activity and resistance profiles evaluated. The most potent analog [5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid (d4AP) demonstrated a HIV EC50 = 2.1 μM, and the most favorable resistance profile against HIV-1 variants with K65R, M184V or multiple thymidine analog mutations in RT.
Synthesis of 2'-deoxyuridine and 5-fluoro-2'-deoxyuridine derivatives and evaluation in antibody targeting studies
Henn,Garnett,Chhabra,Bycroft,Baldwin
, p. 1570 - 1579 (2007/10/02)
Derivatives of 2'-deoxyuridine and of the anticancer agent 5-fluoro-2'- deoxyuridine (FdUR) were linked indirectly via a human serum albumin carrier (HSA) to the murine antiosteosarcoma monoclonal antibody 791T/36. Starting from the 2'-deoxyuridines 1a an
