20107-66-8

Basic information

• Product Name: 3-(3-chloro-phenyl)-4H-[1,2,4]oxadiazol-5-one
• Synonyms: 3-(3-chloro-phenyl)-4H-[1,2,4]oxadiazol-5-one
• CAS NO: 20107-66-8
• Molecular Weight: 196.593
• Mol File: 20107-66-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(3-chloro-phenyl)-4H-[1,2,4]oxadiazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-chloro-phenyl)-4H-[1,2,4]oxadiazol-5-one(20107-66-8)
• EPA Substance Registry System: 3-(3-chloro-phenyl)-4H-[1,2,4]oxadiazol-5-one(20107-66-8)

Safety Data

• Hazardous Substances Data: 20107-66-8(Hazardous Substances Data)

Upstream product

• 22179-77-7 3-chloro-N-hydroxy-benzamidine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 2039-85-2 3-Chlorostyrene 
• 616-38-6 carbonic acid dimethyl ester 

Relevant articles and documents

Tert-Butyl Nitrite Mediated Synthesis of 1,2,4-Oxadiazol-5(4 H)-ones from Terminal Aryl Alkenes

tert-Butyl nitrite (TBN) mediated synthesis of 3-aryl-1,2,4-oxadiazol-5(4H)-ones has been accomplished using terminal aryl alkenes via a biradical reaction intermediate. Three consecutive sp2 C-H bond functionalizations of styrenes afforded 3-phenyl-1,2,4-oxadiazol-5(4H)-ones via the formation of new C?N, C?O, C-O, and two C-N bonds. Both of the N atoms originate from TBN, while the carbonyl oxygen is from the water (moisture) the other oxygen from the N?O part of the TBN.

OXADIAZOLE COMPOUNDS

The present invention relates to a compound of formula (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein R1,R2,R3,L1,L2,L3,L4,L5 and n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, and/or protein misfolding disorders.