201160-41-0

Upstream product

• 3099-28-3 2,6-bis(chloromethyl)pyridine 

Downstream Products

• 1350538-43-0 (4R,9R,12S)-12-benzyl-3,13-bis(2-nitrobenzenesulfonyl)-19-oxo-3,10,13,19-tetraazatricyclo[13.3.1.0(4,9)]-nonadeca-1⁽¹⁹⁾,15,17-trien-11-one 
• 1350538-46-3 (4R,9R)-12-benzyl-19-oxy-3,10,13,19-tetraazatricyclo[13.3.1.0(4,9)]nonadeca-1⁽¹⁹⁾,15,17-trien-11-one 
• 1350538-44-1 (4R,9R,12S)-12-isopropyl-3,13-bis(2-nitrobenzenesulfonyl)-19-oxy-3,10,13,19-tetraazatricyclo[13.3.1.0(4,9)] nonadeca-1⁽¹⁹⁾,15,17-trien-11-one 
• 1350538-45-2 (4R,9R)-3,13-bis(2-nitrobenzenesulfonyl)-19-oxy-3,10,13,19-tetraazatricyclo[13.3.1.0(4,9)]nonadeca-1⁽¹⁹⁾,15,17-trien-11-one 
• 1350538-52-1 (4S,7R,12R,15S)-4,15-dibenzyl-3,16-bis(2-nitrobenzenesulfonyl)-2-oxo-3,6,13,16,22-pentaazatricyclo[16.3.1.0(7,12)]docosa-1⁽²¹⁾,18⁽²²⁾,19-trien-5,14-dione 
• 1350538-56-5 (4S,7R,12R,15S)-4,15-dibenzyl-22-oxy-3,6,13,16,22-pentaazatricyclo[16.3.1.0(7,12)]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-5,14-dione 
• 1350538-53-2 C₃₅H₄₃N₇O₁₁S₂ 
• 1350538-54-3 (7R,12R)-3,16-bis(2-nitrobenzenesulfonyl)-23-oxo-3,6,13,16,22-pentaazatricyclo[16.3.1.0(7,12)]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-5,14-dione 

Relevant academic research and scientific papers

Ready available chiral azapyridinomacrocycles n-oxides; First results as lewis base catalysts in asymmetric allylation of p-nitrobenzaldehyde

We report here the straightforward synthesis of the first series of enantiomerically pure azapyridinomacrocycles N-oxides containing a cyclohexyl chiral moiety. These compounds were readily obtained in good overall yields by a convergent synthesis using natural amino acids as starting building blocks and macrocyclisation as the key step. This method is rapid, efficient and suitable for the introduction of various substituents at the macrocyclic skeleton. Finally, the compounds were tested as organocatalysts for the enantioselective allylation of p-nitrobenzaldehyde with allyltrichlorosilane.

Synthesis of trifunctional ligands containing thiophosphoryl, pyridine and pyridine N-oxide donor groups

The trifunctional mixed donor ligands 2,6-[R2P(S)CH2]2C5H3N 1 (R = Ph 1a, Tol 1b, n-Bu, 1c) and 2,6-[R2P(S)-CH2]2C5H3NO 2 (R = Ph 2a, Tol 2b, n-Bu, 2c) have been prepared and characterized by spectroscopic (MS, IR, NMR) techniques. The coordination chemistry of one derivative 1a has been examined and the complex {[Ph2P(S)-CH2]2 C5H3N} Ni(NO3)2 has been crystallized and characterized by single-crystal X-ray diffraction methods. The structure contains a six coordinate Ni(II) ion bonded to a tridentate ligand 1a with Ni-Npyr 2.110(3) A and Ni-S 2.481(1) and 2.402(1) A, a bidentate nitrate anion and a monodentate NO3- anion.