201160-58-9

Basic information

• Product Name: N-benzyl-5-(trifluoromethyl)pyridin-2-amine
• Synonyms: N-benzyl-5-(trifluoromethyl)pyridin-2-amine
• CAS NO: 201160-58-9
• Molecular Formula: C₁₃H₁₁F₃N₂
• Molecular Weight: 252.2350496
• Mol File: 201160-58-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzyl-5-(trifluoromethyl)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-5-(trifluoromethyl)pyridin-2-amine(201160-58-9)
• EPA Substance Registry System: N-benzyl-5-(trifluoromethyl)pyridin-2-amine(201160-58-9)

Safety Data

• Hazardous Substances Data: 201160-58-9(Hazardous Substances Data)

Upstream product

• 74784-70-6 2-amino-5-trifluoromethylpyridine 
• 100-51-6 benzyl alcohol 
• 100-46-9 benzylamine 
• 50488-42-1 2-bromo-5-(trifluoromethyl)pyridine 

Relevant articles and documents

Water-promoted dehydrative coupling of 2-aminopyridines in heptane: Via a borrowing hydrogen strategy

A synthetic method for dehydrative N-benzylation promoted by water molecules in heptane using a π-benzylpalladium system has been developed. The presence of water significantly accelerates carbon-nitrogen bond formation, which is accomplished in an atom-economical process to afford the corresponding N-monobenzylated products. A crossover experiment afforded H/D scrambled products, which is consistent with a borrowing hydrogen mechanism. Kinetic isotope effect measurements revealed that benzylic carbon-hydrogen bond cleavage was the rate-determining step.

A metal-free tandem demethylenation/C(sp2)-H cycloamination process of N -Benzyl-2-aminopyridines via C-C and C-N bond cleavage

A mild, metal-free synthesis of pyrido[1,2-a]benzimidazoles starting with N-benzyl-2-aminopyridines, which employs PhI(OPiv)2 as a stoichiometric oxidant, has been developed. The process is initiated by an unusual PhI(OPiv)2-mediated ipso SEAr reaction, followed by solvent-assisted C-C and C-N bond cleavage.