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2,2-Dimethyl-4-isopropyl-1,3-benzodioxole (Propofol Impurity L) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

201166-22-5

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201166-22-5 Usage

Uses

Different sources of media describe the Uses of 201166-22-5 differently. You can refer to the following data:
1. Propofol impurity L
2. 2,2-Dimethyl-4-isopropyl-1,3-benzodioxole (Propofol EP Impurity L).

Check Digit Verification of cas no

The CAS Registry Mumber 201166-22-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,1,6 and 6 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 201166-22:
(8*2)+(7*0)+(6*1)+(5*1)+(4*6)+(3*6)+(2*2)+(1*2)=75
75 % 10 = 5
So 201166-22-5 is a valid CAS Registry Number.

201166-22-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2-dimethyl-4-propan-2-yl-1,3-benzodioxole

1.2 Other means of identification

Product number -
Other names UNII-IA7O19V7ZY

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:201166-22-5 SDS

201166-22-5Synthetic route

3-isopropylbenzene-1,2-diol
2138-48-9

3-isopropylbenzene-1,2-diol

2,2-dimethyl-4-(1-methylethyl)-1,3-benzodioxole
201166-22-5

2,2-dimethyl-4-(1-methylethyl)-1,3-benzodioxole

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In acetone at 0 - 20℃; for 16h;71%
2-(1-methylethyl)phenol
88-69-7

2-(1-methylethyl)phenol

2,2-dimethyl-4-(1-methylethyl)-1,3-benzodioxole
201166-22-5

2,2-dimethyl-4-(1-methylethyl)-1,3-benzodioxole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / N,N-dimethyl-formamide / 0.25 h / 20 °C
1.2: 1.17 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: acetic acid / 0.5 h / 0 °C
3.2: 4 h / 0 - 20 °C
4.1: toluene-4-sulfonic acid / methanol / 6 h / 20 °C
5.1: boron trifluoride diethyl etherate / acetone / 16 h / 0 - 20 °C
View Scheme
C15H25BO4

C15H25BO4

2,2-dimethyl-4-(1-methylethyl)-1,3-benzodioxole
201166-22-5

2,2-dimethyl-4-(1-methylethyl)-1,3-benzodioxole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic acid / 0.5 h / 0 °C
1.2: 4 h / 0 - 20 °C
2.1: toluene-4-sulfonic acid / methanol / 6 h / 20 °C
3.1: boron trifluoride diethyl etherate / acetone / 16 h / 0 - 20 °C
View Scheme
1-isopropyl-2-(methoxymethoxy)benzene
74931-59-2

1-isopropyl-2-(methoxymethoxy)benzene

2,2-dimethyl-4-(1-methylethyl)-1,3-benzodioxole
201166-22-5

2,2-dimethyl-4-(1-methylethyl)-1,3-benzodioxole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: acetic acid / 0.5 h / 0 °C
2.2: 4 h / 0 - 20 °C
3.1: toluene-4-sulfonic acid / methanol / 6 h / 20 °C
4.1: boron trifluoride diethyl etherate / acetone / 16 h / 0 - 20 °C
View Scheme

201166-22-5Downstream Products

201166-22-5Relevant academic research and scientific papers

Commercial manufacturing of propofol: Simplifying the isolation process and control on related substances

Pramanik, Chinmoy,Kotharkar, Sandeep,Patil, Pradip,Gotrane, Dinkar,More, Yogesh,Borhade, Ajit,Chaugule, Balaji,Khaladkar, Tushar,Neelakandan,Chaudhari, Ashok,Kulkarni, Mukund G.,Tripathy, Narendra K.,Gurjar, Mukund K.

supporting information, p. 152 - 156 (2014/05/20)

A commercially viable manufacturing process for propofol (1) is described. The process avoids acid-base neutralization events during isolation of intermediate, 2,6-di-isopropylbenzoic acid (3) and crude propofol, and thus simplifies the synthesis on industrial scale to a considerable extent. Syntheses of five impurities/related substances (USP and EP) are also described.

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