2012-77-3 Usage
Uses
Used in Pharmaceutical Industry:
2-(2,3-Dichlorophenyl)propionic acid is used as a nonsteroidal anti-inflammatory drug (NSAID) for its ability to relieve pain and reduce inflammation in conditions such as arthritis and musculoskeletal disorders. It is valued for its effectiveness in managing these conditions by inhibiting the production of prostaglandins, which are the primary mediators of pain and inflammation in the body.
Used in Pain Management:
In the field of pain management, 2-(2,3-Dichlorophenyl)propionic acid serves as an analgesic agent, helping to alleviate discomfort and pain associated with various conditions. Its mechanism of action involves the inhibition of prostaglandin synthesis, thereby reducing the sensation of pain.
Used in Inflammation Reduction:
2-(2,3-Dichlorophenyl)propionic acid is also used in the reduction of inflammation, where it plays a crucial role in diminishing the swelling and redness associated with inflammatory conditions. By targeting the prostaglandin production, it helps to control the inflammatory response and provide relief to affected individuals.
Check Digit Verification of cas no
The CAS Registry Mumber 2012-77-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,1 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2012-77:
(6*2)+(5*0)+(4*1)+(3*2)+(2*7)+(1*7)=43
43 % 10 = 3
So 2012-77-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H8Cl2O2/c1-5(9(12)13)6-3-2-4-7(10)8(6)11/h2-5H,1H3,(H,12,13)
2012-77-3Relevant academic research and scientific papers
2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists
Ann, Jihyae,Bahrenberg, Gregor,Blumberg, Peter M.,Choi, Sun,Christoph, Thomas,Do, Nayeon,Frank-Foltyn, Robert,Ha, Heejin,Jeong, Jin Ju,Kang, Jin Mi,Kim, Changhoon,Kwon, Sun Ok,Lee, Jeewoo,Lee, Sunho,Lesch, Bernhard,Stockhausen, Hannelore,Vu, Thi Ngoc Lan,Yoon, Sanghee
, (2021/07/28)
A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.
