201206-40-8

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 401-55-8 ethyl bromofluoroacetate 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 37032-34-1 2-fluoro-1-(4-methylphenyl)ethanone 

Downstream Products

• 1612838-56-8 2-fluoro-2-phenyl-1-(p-tolyl)ethane-1-one 

Relevant academic research and scientific papers

Nickel-Catalyzed Coupling Reaction of α-Bromo-α-fluoroketones with Arylboronic Acids toward the Synthesis of α-Fluoroketones

A nickel-catalyzed coupling reaction of α-bromo-α-fluoroketones with arylboronic acids was reported, which provides an efficient pathway to access 2-fluoro-1,2-diarylethanones in high yields. We also disclosed the synthesis of the monofluorination agents

Method for synthesizing monofluorobromoacetone derivative by applying Grignard reagent

The invention provides a method for synthesizing a monofluorobromoacetone derivative by applying a Grignard reagent. The method is characterized by comprising the steps that ethyl monofluorobromoacetate is dissolved into anhydrous THF, replacing is conducted 3-4 times with nitrogen, the Grignard reagent is dropwise added at -78-0 DEG C for a reaction, and the monofluorobromoacetone derivative is obtained after treatment; the structural formula of the ethyl monofluorobromoacetate is the formula (I), the structural formula of the Grignard reagent is the formula (II), the structural formula of the monofluorobromoacetone derivative is the formula (III), and the formulas are defined in the description, wherein R1 is phenyl or naphthalene or substituted phenyl or alkyl or heterocyclic, and the substituent in the substituted phenyl is selected from one or multiple of hydrogen, fluorine, bromine, chlorine, trifluoromethoxy, methoxy, methyl and phenyl. The method has the advantages of being high in yield, short in reaction time, simple in preparation method, convenient, efficient, easy to implement, suitable for industrial production and capable of being applied to the fields of medicine, pesticide and the like.

α,α-Alkylation-Halogenation and Dihalogenation of Sulfoxonium Ylides. A Direct Preparation of Geminal Difunctionalized Ketones

A one-pot alkylation–halogenation of ketosulfoxonium ylides in the presence of alkyl halides is described. The method furnishes several gem-difunctionalized haloketones (an alkyl and F, Cl, Br, or I) in good yields. Replacing alkyl halides with a mixture of electrophilic halogen species and various halide anions led to gem-dihalogenated ketones containing a combination of the same or two different halogens. Kinetic isotopic effects as well as reaction kinetic experiments give insight to the mechanism of these reactions.

Reactions of 1-aryl-2,2-dihalogenoethanone oximes with tetrasulfur tetranitride (S4N4): A general method for the synthesis of 3-aryl-4-halogeno-1,2,5-thiadiazoles

1-Aryl-2,2-dichloro-7, 1-aryl-2,2-dibromo-8, 1-aryl-2-bromo-2-fluoro-9 and 1-aryl-2-chloro-2-fluoroethanone oximes 10 have been prepared by allowing the corresponding ketones to react with hydroxylamine hydrochloride in EtOH at room temperature. Stereoche