201208-29-9

Upstream product

• 85026-58-0 (1R,5R,6R,7S)-6,7-(isopropylidenedioxy)-3-oxabicyclo[3.2.1]octane-2-one 
• 50345-02-3 (1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarbonitrile 
• 225091-45-2 [(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentyl]methanol 
• 225091-47-4 (3aS,4S,6R,6aR)-4-Diazomethyl-2,2-dimethyl-6-trityloxymethyl-tetrahydro-cyclopenta[1,3]dioxole 
• 225091-46-3 C₃₁H₃₄N₂O₅ 
• 201208-27-7 N-{[(1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentyl]methyl}acetamide 
• 201208-25-5 (1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarboxamide 
• 76-83-5 trityl chloride 
• 201208-28-8 methyl 3-[(1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentyl]-1H-pyrazole-5-carboxylate 

Relevant academic research and scientific papers

Chiral synthons for CARBA-β-D-ribonucleosides. Synthesis of CARBA-4- deoxypyrazofurin and isomeric CARBA-4-deaza-oxoformycin analogues

Multi-step transformation of enantiomerically pure synthons, (1S,2S,3R,4R)-(4-hydroxymethyl-2,3-isopropylidenedioxy-1-cyclopentyl) methyl butyrate {(-)-5} and (1R,5R,6R,7S)-6,7-(isopropylidenedioxy)-3- oxabicyclo[3.2.1]octane-2-one {(+)-11} into carba-4-deoxypyrazofurin 1 and isomeric carba-4-deaza-oxoformycin 2 analogues is presented.

Approach to carbocyclic 4-deoxypyrazofurin through asymmetrisation of a meso-norbornene derivative

The first enantioselective synthesis of carbocyclic 4-deoxypyrazofurin 1a has been accomplished via ketone (+)-4 which was prepared by asymmetric hydroboration or hydrosilylation reactions.