201221-73-0Relevant academic research and scientific papers
A facile one-pot synthesis of α-fluoro-α,β-unsaturated esters from alkoxycarbonylmethyltriphenylphosphonium bromides
Suzuki, Yumiko,Sato, Masayuki
, p. 1679 - 1681 (2004)
A convenient one-pot synthesis of α-fluoro-α, β-unsaturated esters from ethoxy- and tert- butoxycarbonylmethyltriphenylphosphonium bromide was developed. The fluorinated phosphoranes, generated in situ from alkoxycarbonylmethyltriphenylphosphonium bromides and 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor), undergo a Wittig reaction with aldehydes to yield α-fluoro-α,β-unsaturated esters with (Z)-selectivity.
