201286-64-8

Basic information

• Product Name: 3,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE
• Synonyms: 3,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE;3,5-dimethylpyridine-4-carbaldehyde;4-Pyridinecarboxaldehyde,3,5-dimethyl-(9CI);3,5-dimethyl-4-pyridinecarboxaldehyde;3,5-Dimethylisonicotinaldehyde
• CAS NO: 201286-64-8
• Molecular Formula: C8H9NO
• Molecular Weight: 135.16
• Product Categories: PYRIDINE;Pyridines
• Mol File: 201286-64-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 252.8 ºC at 760 mmHg
• Flash Point: 113.3ºC
• Appearance: /
• Density: 1.065 g/cm³
• Vapor Pressure: 0.0189mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.83±0.28(Predicted)
• CAS DataBase Reference: 3,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE(201286-64-8)
• EPA Substance Registry System: 3,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE(201286-64-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 201286-64-8(Hazardous Substances Data)

Usage

General Description

"3,5-Dimethylpyridine-4-carboxaldehyde" is an organic compound with the CAS registry number 1124-62-9. It is a relatively stable chemical, important in the field of organic compound synthesis. The chemical is often used in the creation of other, complex organic compounds, and as such is a vital tool in chemistry. It is part of the pyridine family, one of which's properties include being miscible with water, making it useful in a variety of chemical reactions. Studies on its properties, such as melting and boiling point, structure, and spectra data, have been conducted for application in the pharmaceutical industry and synthetic chemistry. As with many chemicals, it must be handled correctly to ensure safety.

InChI:InChI=1/C8H9NO/c1-6-3-9-4-7(2)8(6)5-10/h3-5H,1-2H3

Upstream product

• 201286-65-9 4-bromo-3,5-dimethylpyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 591-22-0 3,5-Lutidine 

Relevant articles and documents

Halogen Bonding Molecular Capsules

Molecular capsules based solely on the interaction of halogen bonding (XB) are presented along with their host-guest binding properties in solution. The first example of a well-defined four-point XB supramolecular system is realized by decorating resorcin[4]arene cavitands with polarized halogen atoms for dimerization with tetra(4-pyridyl) resorcin[4]arene cavitands. NMR binding data for the F, Cl, Br, and I cavitands as the XB donor show association constants (Ka) of up to 5370 M-1 (ΔG283 K=-4.85 kcal mol-1, for I), even in XB-competitive solvent, such as deuterated benzene/acetone/methanol (70:30:1) at 283 K, where comparable monodentate model systems show no association. The XB capsular geometry is evidenced by two-dimensional HOESY NMR, and the thermodynamic profile shows that capsule formation is enthalpically driven. Either 1,4-dioxane or 1,4-dithiane are encapsulated within each of the two separate cavities within the XB capsule, with of up to Ka=9.0 108 M-2 (ΔG283 K=-11.6 kcal mol-1).

Substituted azabicyclic compounds

This invention is directed to certain physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring is an azaheterocycle, and the ring represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; and N-oxides thereof, and their prodrugs, and pharmaceutically acceptable salts and solvates of the compounds of formula (I) and N-oxides thereof, and their prodrugs. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.