201287-92-5

Upstream product

• 1078156-82-7 6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 57-13-6 urea 
• 253453-32-6 2-(3,4,5-trimethoxy)phenyltetrahydro-(2H)-1,3-oxazine 

Downstream Products

• 1388627-75-5 (4S)-5-ethoxycarbonyl-6-methyl-4-(3,4,5-trimethoxyphenyl)-1-[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenylpropionyl]-3,4-dihydropyrimidin-2(1H)-one 
• 1388627-76-6 (4R)-5-ethoxycarbonyl-6-methyl-4-(3,4,5-trimethoxyphenyl)-1-[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenylpropionyl]-3,4-dihydropyrimidin-2(1H)-one 
• 1254120-61-0 ethyl 3-formyl-6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1254120-72-3 ethyl 3-benzoyl-6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1254120-73-4 C₁₉H₁₈N₂O₅ 
• 1078156-82-7 6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Deep eutectic solvent mediated synthesis of 3,4-dihydropyrimidin-2(1H)-ones and evaluation of biological activities targeting neurodegenerative disorders

Substitution of hazardous and often harmful organic solvents with “green” and “sustainable” alternative reaction media is always desirous. Ionic liquids (IL) have emerged as valuable and versatile liquids that can replace most organic solvents in a variet

Synthesis and Evaluation of Dihydropyrimidinones and Their Derivatives against Meloidogyne incognita

3,4-Dihydropyrimidin-2-ones (DHPMs) were synthesized in good yield using ammonium molybdate as a catalyst under different reaction conditions through ultrasonication technique. Dehydrogenated derivatives of DHPMs, that is, pyrimidin-2-ones were synthesize

Dihydropyrimidinones: Efficient one-pot green synthesis using Montmorillonite-KSF and evaluation of their cytotoxic activity

A simple, efficient, cost-effective, recyclable and green approach has been developed for the synthesis of new dihydropyrimidinone analogs via the Biginelli reaction. The methodology involves a multicomponent reaction catalyzed by "HPA-Montmorillonite-KSF"as a reusable and heterogeneous catalyst. This method gives an efficient and much improved modification of the original Biginelli reaction, in terms of yield and short reaction times under solvent free conditions. All the derivatives were subjected to cytotoxicity screening against a panel of four different human cancer cell lines viz. colon (Colo-205), prostate (PC-3), leukemia (THP-1) and lung (A549) to check their effect on percentage growth. MTT [3-(4,5-dimethylthiazol-yl)-diphenyl tetrazoliumbromide] cytotoxicity assay was employed to check IC50 values. Of the synthesized analogs, 16a showed the best activity with IC50 of 7.1 ± 0.8, 13.1 ± 1.4, 13.8 ± 0.9 and 14.7 ± 1.1 μM against lung (A549), leukemia (THP-1), prostate (PC-3) and colon (Colo-205) cancer lines, respectively. The 16a analog was further checked for its effect on cancer cell properties through clonogenic (colony formation) and scratch motility (wound healing) assays and thereby was found that it reduced both the colony formation and migratory properties of the lung cancer cell line (A549). Further, molecular docking studies were performed with 16a to show its binding mode. This journal is

Synthesis and catalytic application of D-glucose derived ytterbium(III) complex in Biginelli reaction

4,6-O-Ethylidene-N-(2-hydroxybenzylidene)-β-D-glucopyranosylamine has been reacted with ytterbium(III) acetate and the resultant complex has been used as catalyst in the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs). Twenty-one DHPMs have been synthesised under neat reaction condition in appreciable yields (73–96percent) and reusability of the catalyst has been established.

A comparative study between Cu(INA)2-MOF and [Cu(INA)2(H2O)4] complex for a click reaction and the Biginelli reaction under solvent-free conditions

The catalytic activity of metal-organic framework Cu(INA)2 (INA = isonicotinate ion) and the complex [Cu(INA)2(H2O)4] were studied in the Copper-catalyzed Azide-Alkyne Cycloaddition (CuAAC) and Biginelli reactio

Novel catalytic application of Ni@ZnO nanoparticles and ZnO nanoflakes in aqueous solution of NaPTS hydrotrope at room temperature via a green synthesis of 3,4-dihydropyrimidin-2(1H)-ones

We investigated a novel catalytic application of nickel-doped zinc oxide (Ni-ZnO) nanoparticles and zinc oxide (ZnO) nanoflakes at room temperature in an aqueous hydrotropic solution for the synthesis of biologically active dihydropyrimidones (DHPMs). Ni-

Halogenated macroporous sulfonic resins as efficient catalysts for the Biginelli reaction

A series of halogenated macroporous sulfonic resins A-15-Cl, A-15-Br and A-15-I were synthesized from the precursor Amberlyst 15 by a typical halogenation reaction, and they were evaluated for the catalytic activities of the halogenated macroporous sulfon

Heterogenized hybrid catalyst of 1-sulfonic acid-3-methyl imidazolium ferric chloride over NaY zeolite for one-pot synthesis of 2-amino-4-arylpyrimidine derivatives: A viable approach

A new hybrid material of NaY zeolite supported 1-sulfonic acid-3-methyl imidazolium ferric chloride [Msim][FeCl4] has been developed by modifying the zeolite surface with six different w/w ratios through wet impregnation method. These composite

A facile synthesis of 3,4-dihydropyrimidinones/thiones and novel N-dihydro pyrimidinone-decahydroacridine-1,8-diones catalyzed by cellulose sulfuric acid

A new and efficient method has been developed for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/-thiones (DHPMs) through Biginelli reaction in aqueous media. Furthermore, a new series of N-dihydro pyrimidinone- decahydroacridine-1,8-diones (8a-m) have

Revisit to the Biginelli reaction: A novel and recyclable bioglycerol-based sulfonic acid functionalized carbon catalyst for one-pot synthesis of substituted 3,4-dihydropyrimidin-2-(1H)-ones

A simple and efficient synthetic protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by using a novel bioglycerol-based sulfonic acid functionalized carbon catalyst, devoid of moisture sensitive metal catalysts and corrosive acidic reagents. The developed method has the advantages of good to excellent yields, short reaction times, operational simplicity, and a recyclable catalyst. The catalyst can be prepared by a simple procedure from inexpensive and readily available glycerol and has been shown to be recoverable and reusable up to four cycles without any loss of activity.