201294-55-5Relevant academic research and scientific papers
Design, synthesis and quantitative structure-activity relationship study of N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-carbonyl)guanidine derivatives as potent Na/H exchange inhibitors
Yamamoto, Takeshi,Hori, Manabu,Watanabe, Ikuo,Tsutsui, Hisayoshi,Harada, Kengo,Ikeda, Shoji,Maruo, Joji,Morita, Tominori,Ohtaka, Hiroshi
, p. 1975 - 1983 (2007/10/03)
Inhibition of the Na/H exchanger is a promising approach for treating ischemia-reperfusion injury, but no clinical agent is yet available. Recently, we established the structural requirements for potent inhibitors of the Na/H exchanger. In the present wor
