201353-03-9Relevant academic research and scientific papers
An efficient p-thiocyanation of phenols and naphthols using a reagent combination of phenyliodine dichloride and lead(II) thiocyanate
Kita, Yasuyuki,Takeda, Yoshifumi,Okuno, Takayuki,Egi, Masahiro,Iio, Kiyosei,Kawaguchi, Ken-Ichi,Akai, Shuji
, p. 1887 - 1890 (2007/10/03)
A combination of PhICl2 and Pb(SCN)2 is effective for the p-selective thiocyanation of various types of p-unsubstituted phenols and naphthols 1 to give p-thiocyanatophenols and naphthols 3. The reaction proceeded at 0 °C to room temperature in good to quantitative yields. Twenty-five examples are given, in which various functional groups, such as chloro, allyl, carbonyl, ester, amide, and primary hydroxyl groups are shown to be compatible with this reaction.
