201357-83-7Relevant academic research and scientific papers
Amino Zinc Enolate Carbocyclization Reactions. New Access to Polysubstituted Piperidine Derivatives
Lorthiois, Edwige,Marek, Liane,Normant, Jean F.
, p. 566 - 574 (1998)
Various N-pent-4-enylglycine methyl esters have been submitted to carbocyclization of their zinc enolates onto the unactivated double bond. The cyclization to substituted pipecolic esters is highly stereoselective. In most cases, substitution of the pent-4-enyl moiety on various sites leads to a single isomer, hence a way to di-, tri-, tetra-, or pentasubstituted piperidines.
