201414-32-6

Upstream product

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• 98-59-9 p-toluenesulfonyl chloride 
• 201414-31-5 N,N-diisopropyl-3-hydroxy-2-methylbutanamide 

Relevant academic research and scientific papers

Diastereodivergency in the reactions of 3-metallated-2-methylbutanamide

Diastereocontrolled reactions with 3-iodozinc-2-methylbutanamide were examined. When the iodozinc reagent was reacted with aromatic and α,β- unsaturated aldehydes in the presence of iodotrimethylsilane, C2-C3 anti- derivatives were obtained almost exclusively. Whereas, after transmetallation to Ti(IV), the reaction with aldehydes gave C2-C3 syn-derivatives exclusively. Acylation of the zinc reagent with acid chlorides in the presence of Pd(0) catalyst gave C2-C3 syn-derivatives.