201421-72-9Relevant academic research and scientific papers
Trials for the synthesis of (R)-4-mercapto-pyrrolidin-2-one ((R)-MPD)
Kobayashi, Satoshi,Kobayashi, Katsuhiro,Hirai, Koichi
, p. 909 - 912 (2007/10/03)
Several trials were made for the syntheses of (S)-4-hydroxy-pyrrolidin- 2-one ((S)-HPD) and (R)-4-mercapto-pyrrolidin-2-one ((R)-MPD), a substituent at the 2-position of the orally active carbapenem antibiotic CS-834. The latter was synthesized from prochiral dimethyl or diethyl 3-p- methoxybenzylthioglutarate using pig liver esterase technology to give monoester with an optical purity of 51-71% e.e. as a key intermediate.
