20143-38-8Relevant academic research and scientific papers
Synthesis and biological evaluation of prodrugs for nitroreductase based 4-β-amino-4′-Demethylepipodophyllotoxin as potential anticancer agents
Deng, Wei,He, Dian,Wu, Zheng-Rong
, (2022/01/31)
A series of prodrugs for nitroreductase (NTR) based 4-β-amino-4′- Demethylepipodophyllotoxin as potential anticancer agents were synthesized, and their antiproliferative activities in vitro showed compounds 2b (IC50 = 0.77, 0.83 and 1.19 μM) an
O-nitro aroylation derivative compound, preparation method and application thereof
-
Paragraph 0024; 0032; 0033, (2018/05/07)
The invention discloses a compound, and a preparation method and use of the compound. The compound is the compound d shown as formula II. The target product is synthesized by other iodination method and acyl chloride method. The preparation method needs short time and is simple in operation. Relevant experiments indicate that the compound provided by the invention has antitumor activity, and alsohas the advantages of high selectivity to cells and low toxicity.
