20143-45-7

Upstream product

• 95-77-2 3,4-dichlorophenol 
• 62855-72-5 ethyl 2-(3,4-dichlorophenoxy)acetate 

Downstream Products

• 67141-40-6 N,N-Di-sec-butyl-2-(3,4-dichloro-phenoxy)-acetamide 
• 85630-54-2 5-Chloro-4-[2-(3,4-dichloro-phenoxy)-acetylamino]-N-(2-diethylamino-ethyl)-2-methoxy-benzamide 
• 113912-89-3 2-(3,4-Dichloro-phenoxy)-N-((R)-1-hydroxymethyl-propyl)-acetamide 
• 113912-90-6 2-(3,4-Dichloro-phenoxy)-N-((S)-1-hydroxymethyl-propyl)-acetamide 
• 147234-43-3 11-[2-(3,4-dichlorophenoxy)acetyl]-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole 
• 1246091-28-0 O,O-dimethyl-1-(3,4-dichlorophenoxyacetoxy)-1-(2-chlorophenyl)methylphosphonate 
• 32026-08-7 2-(3,4-dichlorophenoxy)acetamide 
• 1246091-39-3 O,O-dimethyl-1-(3,4-dichlorophenoxyacetoxy)ethylphosphonate 
• 1026821-95-3 2-[2-(3,4-dichloro-phenoxy)-acetylamino]-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester 
• 69764-13-2 2-({[(3,4-dichlorophenyl)oxy]acetyl}amino)benzoic acid 
• 58792-08-8 1-[5-(3,4-dichloro-phenoxymethyl)-[1,2,3]thiadiazole-4-carbonyl]-piperidine 
• 58792-07-7 4-[5-(3,4-dichloro-phenoxymethyl)-[1,2,3]thiadiazole-4-carbonyl]-morpholine 

Relevant academic research and scientific papers

MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra2, Ra4, R

NURR1 RECEPTOR MODULATORS

Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.