201467-04-1Relevant articles and documents
Evaluation of Potent and Selective Small-Molecule Antagonists for the CXCR2 Chemokine Receptor
Widdowson, Katherine L.,Elliott, John D.,Veber, Daniel F.,Nie, Hong,Rutledge, Melvin C.,McCleland, Brent W.,Xiang, Jia-Ning,Jurewicz, Anthony J.,Hertzberg, Robert P.,Foley, James J.,Griswold, Don E.,Martin, Lenox,Lee, Judithann M.,White, John R.,Sarau, Henry M.
, p. 1319 - 1321 (2007/10/03)
N,N′-Diarylureas were prepared, and the structure-activity relationship relative to the CXCR2 receptor was examined. This led to the identification of a potent and highly selective CXCR2 antagonist, which in addition was shown to be functionally active bo
IL-8 RECEPTOR ANTAGONISTS
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, (2008/06/13)
Novel IL-8 receptor antagonists and methods of using them are provided.