201470-29-3

Upstream product

• 98487-89-9 indoline-5-sulfonic acid 

Downstream Products

• 173901-90-1 (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-1-(4-octylthiazol-2-yl)-5-indolinesulfonamide 

Relevant academic research and scientific papers

A concise synthesis of N-(1,3-Thiazol-2-yl) indoline-5-sulfonic acids and sulfonyl chlorides

A general and practical synthetic method was developed for indoline-5-sulfonic acids bearing a thiazole heterocycle attached to the nitrogen atom. Two select sulfonic acids were further converted to their corresponding sulfonyl chlorides, key intermediates to the indoline-5- sulfonamide pharmacophore.