201472-30-2

Basic information

• Product Name: (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-ol
• Synonyms: (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-ol
• CAS NO: 201472-30-2
• Molecular Weight: 356.537
• Mol File: 201472-30-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-ol(201472-30-2)
• EPA Substance Registry System: (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-ol(201472-30-2)

Safety Data

• Hazardous Substances Data: 201472-30-2(Hazardous Substances Data)

Upstream product

• 52813-63-5 (5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 128075-94-5 (R)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}dihydrofuran-2(3H)-one 

Downstream Products

• 201472-20-0 (1R,12R)-7-Benzenesulfonyl-1-benzyloxymethoxy-13-(tert-butyl-diphenyl-silanyloxy)-12-methoxymethoxy-1-[(2S,5S)-5-((S)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecan-6-one 
• 201472-22-2 {(2R,13R)-13-Benzyloxymethoxy-2,8-bis-methoxymethoxy-13-[(2S,5S)-5-((S)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyloxy}-tert-butyl-diphenyl-silane 
• 201472-21-1 (1R,12R)-1-Benzyloxymethoxy-13-(tert-butyl-diphenyl-silanyloxy)-12-methoxymethoxy-1-[(2S,5S)-5-((S)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecan-6-one 
• 201472-35-7 (1R,12R)-1-Benzyloxymethoxy-13-(tert-butyl-diphenyl-silanyloxy)-12-methoxymethoxy-1-[(2S,5S)-5-((S)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecan-6-ol 
• 201472-24-4 (S)-3-{(2R,13R)-13-Benzyloxymethoxy-2,8-bis-methoxymethoxy-13-[(2S,5S)-5-((S)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5-methyl-5H-furan-2-one 
• 201472-38-0 (E)-(4R,15R)-15-Benzyloxymethoxy-4,10-bis-methoxymethoxy-15-[(2S,5S)-5-((S)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-pentadec-2-enoic acid methyl ester 
• 201472-23-3 (4R,15R)-15-Benzyloxymethoxy-4,10-bis-methoxymethoxy-15-[(2S,5S)-5-((S)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-pentadecanoic acid methyl ester 
• 201472-37-9 (2R,13R)-13-Benzyloxymethoxy-2,8-bis-methoxymethoxy-13-[(2S,5S)-5-((S)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecanal 
• 201472-36-8 (2R,13R)-13-Benzyloxymethoxy-2,8-bis-methoxymethoxy-13-[(2S,5S)-5-((S)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecan-1-ol 
• 201472-19-7 ((R)-7-Benzenesulfonyl-2-methoxymethoxy-heptyloxy)-tert-butyl-diphenyl-silane 
• 201472-34-6 tert-Butyl-((R)-2-methoxymethoxy-7-phenylsulfanyl-heptyloxy)-diphenyl-silane 
• 201472-18-6 (R)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methoxymethoxy-heptanoic acid methyl ester 
• 201472-32-4 (R)-7-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-heptanoic acid methyl ester 
• 201472-33-5 (R)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methoxymethoxy-heptan-1-ol 

Relevant articles and documents

Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives

A series of cyclic and acyclic nucleoside analogues derived from 3-hydroxy-4-pyridinone were synthesized using the Vorbrüggen reaction. Iron chelation studies, and antiviral evaluation against a broad panel of viruses, were performed. The pKa value of ligand 25 and the stability constant of the corresponding iron-(III) complex were compared to those of deferiprone. The pFe3+ values were found to be similar. Some compounds showed moderate activity against both wild-type HSV-1 and HSV-2, as well as against a thymidine kinase deficient strain of HSV-1. These results suggest a novel mode of action for this group of nucleoside analogues.

Stereocontrolled total synthesis of an annonacin A-type acetogenin: Pseudoannonacin A?

A stereocontrolled first total synthesis of a diastereomer of the presumed mono-tetrahydrofuran type acetogenin annonacin A, starting with enantiomerically pure precursors, is described. The absolute stereochemistry of the C15-C20 segment corresponding to the tetrahydrofuran ring of the natural product was secured by X-ray crystal structure analysis of an advanced intermediate. The synthetic product (a mixture of epimers at C10) had spectroscopic data identical to that of the natural product, but a different optical rotation.