201472-47-1

Basic information

• Product Name: (6R,7S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-7-(2-carboxy-benzoylamino)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester
• Synonyms: (6R,7S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-7-(2-carboxy-benzoylamino)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester
• CAS NO: 201472-47-1
• Molecular Weight: 530.693
• Mol File: 201472-47-1.mol

Chemical Properties

• CAS DataBase Reference: (6R,7S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-7-(2-carboxy-benzoylamino)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (6R,7S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-7-(2-carboxy-benzoylamino)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester(201472-47-1)
• EPA Substance Registry System: (6R,7S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-7-(2-carboxy-benzoylamino)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester(201472-47-1)

Safety Data

• Hazardous Substances Data: 201472-47-1(Hazardous Substances Data)

Upstream product

• 201472-44-8 [(2R,3S)-2-[4-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-butyl]-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-1-yl]-(diethoxy-phosphoryl)-acetic acid tert-butyl ester 
• 201472-45-9 [(2R,3S)-2-[4-(tert-Butyl-dimethyl-silanyloxy)-3-oxo-butyl]-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-1-yl]-(diethoxy-phosphoryl)-acetic acid tert-butyl ester 
• 201472-43-7 (Diethoxy-phosphoryl)-[(2R,3S)-2-(3,4-dihydroxy-butyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-1-yl]-acetic acid tert-butyl ester 
• 201472-41-5 (Diethoxy-phosphoryl)-[(2S,3S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-hept-6-enoylamino]-acetic acid tert-butyl ester 
• 201472-42-6 [(2R,3S)-2-But-3-enyl-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-1-yl]-(diethoxy-phosphoryl)-acetic acid tert-butyl ester 
• 72292-10-5 tert-butyl 2-amino-2-(diethoxyphosphoryl)acetate 
• 27784-76-5 tert-butyl diethylphosphonoacetate 
• 201472-46-0 (6R,7S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 

Downstream Products

• 201472-50-6 (6R,7S)-7-((R)-2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-3-(tert-butyl-dimethyl-silanyloxymethyl)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Asymmetric Total Synthesis of an Important 3-(Hydroxymethyl)carbacephalosporin

Carbacephalosporins have gained much attention as important antibacterial agents. Recently, 3-(hydroxymethyl)carbacephalosporins have been linked to quinolones for the production of multifunctional antibiotics. A short, practical asymmetric total synthesis of carbacephalosporin 3, suitable for conjugating to other chemical moieties, is reported. The synthesis was achieved by Mitsunobu cyclization of dipeptide 12, prepared from L-erythro-anti-β-hydroxy-α-amino acid 11, and subsequent Horner-Wadsworth-Emmons cyclization of ketone 16.