20151-01-3

Usage

Uses

Used in Pharmaceutical Applications:
1-(4-nitrophenyl)-2-(pyridin-2-yl)ethanol is used as a potential pharmaceutical agent for its possible anti-inflammatory and analgesic properties. Its biological activity makes it a candidate for the development of new drugs targeting inflammation and pain.
Used in Organic Synthesis:
In the field of organic chemistry, 1-(4-nitrophenyl)-2-(pyridin-2-yl)ethanol is used as a reagent in various chemical reactions. Its unique structure allows it to participate in a range of synthetic processes, contributing to the creation of diverse chemical products.
Used in Chemical Research:
1-(4-nitrophenyl)-2-(pyridin-2-yl)ethanol is also utilized in chemical research as a model for studying the effects of structural modifications on the biological activity of phenol and pyridine derivatives. Understanding these effects can guide the design of more effective pharmaceutical drugs and other chemical products.

Upstream product

• 109-06-8 α-picoline 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 109-06-8 α-picoline 
• 555-16-8 4-nitrobenzaldehdye 

Relevant academic research and scientific papers

Magnetically separable CuFe2O4 nanoparticles as a recoverable catalyst for the addition reaction of C(sp3)-H bond of azaarenes to aldehydes

A green and efficient protocol for the copper ferrite (CuFe2O4) nanoparticle-catalyzed direct C(sp3)-H bond functionalization of 2-alkyl azaarenes has been developed. The magnetic catalyst can be recovered and recycled by a simple magnetic separation from the reaction solution and reused eight times without significant decrease in catalytic activity. This journal is

Lewis-acid-catalyzed benzylic reactions of 2-methylazaarenes with aldehydes

Lewis-acid-catalyzed benzylic reactions of 2-methylazaarenes with aldehydes have been investigated. Series of azaarene derivatives were afforded by this reaction. 2-(Pyridin-2-yl)ethanols with common substituents were formed through the LiNTf2-promoted aldol reaction for the first time. 2-Alkenylpyridines, exclusively in the form of the E isomers, were synthesized in the presence of LiNTf2 cooperated with H2NTf. In the presence of La(Pfb)3 as catalysis, 2-alkenylquinolines were obtained in high yields through the reactions between 2-methylquinolines and aldehydes under air.

Acid ionic liquid promoted addition of C(sp3)-H bond to aldehyde

A novel protocol for acid ionic liquid promoted C(sp3)-H bond functionalization of alkyl azaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields, which provides an efficient approach for the synthesis of alkyl-substituted azaarene derivatives. It is worthwhile to note that acid ionic liquid used for this reaction can be recycled and reused six times without a significant decrease in activity.

Microwave assisted water mediated benzylic C-H functionalization of methyl aza-arenes and nucleophilic addition to aromatic aldehydes

A highly efficient method is described for the sp3 C-H bond functionalization of methyl aza-arenes in the presence of water under microwave irradiation and subsequent addition to aromatic aldehydes. This transformation represents an efficient way to synthesize 2-alkyl aza-arene derivatives from simple starting materials.

Bronsted acid promoted benzylic C-H bond functionalization of azaarenes: Nucleophilic addition to aldehydes

A practical Bronsted acid promoted benzylic C-H functionalization of 2-methylazaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields. A six-membered hydrogen-bonding transition state is proposed to be crucial for the reaction. Ready availability of the two starting materials, the use of acetic acid as the catalyst and the facile reaction conditions will guarantee this synthetic method attractive to the synthesis of bioactive pyridine and quinoline derivatives.

AN ALDOL-TYPE REACTION OF ACTIVE METHYL GROUPS OF NITROGEN-CONTAINING HETEROAROMATIC COMPOUNDS

Active methyl groups of nitrogen-containing heteroaromatic compounds react with benzaldehydes in the presence of 9-BBN triflate and diisopropylethylamine in dichloromethane to give the corresponding aldol-type products under mild conditions.