201667-32-5

Upstream product

• 201667-28-9 N⁶-phenoxyacetyl-3’,5’-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2’-O-(methylthiomethyl)adenosine 
• 119824-65-6 N⁶-phenoxyacetyladenosine 
• 131474-68-5 N⁶-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine 

Downstream Products

• 201667-42-7 N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-methylsulfanylmethoxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-2-phenoxy-acetamide 

Relevant academic research and scientific papers

An azidomethyl protective group in the synthesis of oligoribonucleotides by the phosphotriester method

A rapid and effective method of an automatic oligoribonucleotide synthesis alternative to the phosphoramidite one was developed. This method is based on the phosphotriester approach to internucleotide bond formation under intramolecular O-nucleophilic cat

2'-O-methylthiomethyl modifications in hammerhead ribozymes

The synthesis of all four phosphoramidites of 2'-O-methylthiomethyl ribonucleosides and their incorporation into hammerhead ribozymes and influence on nuclease stability and catalytic activity is described.