2017-94-9

Usage

Physical state

White crystalline solid

Classification

N-substituted acetamides

Usage

Pharmaceutical research and development, particularly in the field of medicinal chemistry

Potential applications

Drug targeting specific biological pathways or activities

Current status of properties and effects

Still being studied and not yet fully understood

Upstream product

• 6780-38-7 N-phthaloylglycine chloride 
• 62-53-3 aniline 
• 4702-13-0 N-phthaloylglycine 
• 1074-82-4 potassium phtalimide 
• 587-65-5 N-chloroacetyl-aniline 
• 78425-85-1 (N,N-phthaloyl-glycyl)-phosphoric acid dibenzyl ester 

Downstream Products

• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 555-48-6 2-amino-N-phenyl-acetamide 
• 99275-69-1 o-(N-phenylcarboxamidomethylcarbamoyl)benzoic acid 
• 1469894-58-3 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 7-oxo-7-(2-oxo-2-(phenylamino)ethylamino)heptanoate 
• 1469894-69-6 7-(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-5-hydroxy-4-oxo-4H-chromen-3-yl 7-oxo-7-(2-oxo-2-(phenylamino)ethylamino)heptanoate 

Relevant academic research and scientific papers

PEG-600 mediated facile and green synthesis of novel imide derivatives and their biological activity evaluation

Facile and green syntheses of novel 2-(1,2-benzisothiazole-3-one-1,1- dioxide)-N-arylacetamides, 2-(1,3- dioxoisoindolin-2-yl)-N-arylacetamides and 2-(N-(2-oxo-2-(arylamino)ethyl)sulfamoyl (or) carbamoyl)benzoic acids have been developed and tested for th

Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors

The increasing occurrence of drug-resistant bacterial infections in the clinic has created a need for new antibacterial agents. Natural products have historically been a rich source of both antibiotics and lead compounds for new antibacterial agents. The natural product simocyclinone D8 (SD8) has been reported to inhibit DNA gyrase, a validated antibacterial drug target, by a unique catalytic inhibition mechanism of action. In this work, we have prepared simplified flavone-based analogues inspired by the complex natural product and evaluated their inhibitory activity and mechanism of action. While two of these compounds do inhibit DNA gyrase, they do so by a different mechanism of action than SD8, namely DNA intercalation.

The synthesis and anticonvulsant activity of some omega-phthalimido-N-phenylacetamide and propionamide derivatives.

In this study, by combining anilide and N', N'-phthaloylglycinamide pharmacophores which are known to produce potent anticonvulsant compounds, sixteen omega-phthalimido-N-phenylacetamide and propionamide derivatives bearing substituents at positions 2 or 2, 6 on N-phenyl ring have been synthesized. The structural confirmation of the title compounds was achieved by interpretation of spectral and analytical data. The anticonvulsant activity of the title compounds was determined against maximal electroshock seizure at 100 mg/kg dose level in mice. The preliminary screening results indicated that omega-phthalimido-N-phenylacetamide and propionamide nuclei have pronounced anticonvulsant activity against maximal electroshock seizure.

THE SYNTHESIS OF AMIDES, ESTERS, AND THIOESTERS

Diethyl 2-(3-oxo-2,3-dihydro-1,2-benzisosulfonazolyl)phosphonate is a highly reactive condensing agent, which provides good yield route to amides, esters, and thioesters from a variety of amines, active hydroxylamines, and thiols and acids.

4-Hydroxy-1(2H)-isoquinolone-3-carboxamides. Synthesis and Properties

Reaction of some α-phthalimidoacetamides 1a-i with sodium ethoxide was carried out under drastic conditions.Compounds 1b-g afforded 4-hydroxy-1(2H)-isoquinolone-3-carboxamides 2b-g, while 1h-i afforded the acids 3a-b together with the expected isoquinolon