201735-24-2

Basic information

• Product Name: Benzenamine, N,N-dimethyl-2-(1-octynyl)-
• CAS NO: 201735-24-2
• Molecular Formula: C16H23N
• Molecular Weight: 229.365
• Mol File: 201735-24-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenamine, N,N-dimethyl-2-(1-octynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N,N-dimethyl-2-(1-octynyl)-(201735-24-2)
• EPA Substance Registry System: Benzenamine, N,N-dimethyl-2-(1-octynyl)-(201735-24-2)

Safety Data

• Hazardous Substances Data: 201735-24-2(Hazardous Substances Data)

Upstream product

• 629-05-0 n-octyne 
• 698-02-2 N,N-dimethyl-o-iodoaniline 

Downstream Products

• 1448145-40-1 2-hexyl-N-methyl-3-(phenylselenyl)-1H-indole 
• 1346164-99-5 2-hexyl-1-methyl-3-(phenylthio)-1H-indole 

Relevant articles and documents

Palladium(II)-catalyzed cyclizative cross-coupling of ortho-alkynylanilines with ortho-alkynylbenzamides under aerobic conditions

Born to couple: The Pd(OAc)2-catalyzed reaction of o-alkynylanilines (1) with o-alkynylbenzamides (2) affords the cyclizative cross-coupling products 3 in good to excellent yields. Three bonds are created in the formation of two heterocycles tethered by a tetrasubstituted double bond. Mechanistic studies indicate that the reaction is initiated by aminopalladation with subsequent oxypalladation, N-demethylation, and reductive elimination. Copyright

Synthesis of: N -alkyl-3-sulfonylindoles and N -alkyl-3-sulfanylindoles by cascade annulation of 2-alkynyl- N, N -dialkylanilines

An efficient and metal-free approach to N-alkyl-3-sulfonylindoles and N-alkyl-3-sulfanylindoles from 2-alkynyl-N,N-dialkylanilines has been developed. In the presence of iodine and tert-butylhydroperoxide (TBHP), a variety of 2-alkynyl-N,N-dialkylanilines underwent a cascade radical annulation to yield 3-arylsulfonylindoles. In contrast, 3-arylsulfanylindoles were conveniently prepared by iodine mediated electrophilic annulation reactions. The present protocol uses the economical and environmentally friendly I2-TBHP or I2 system, and potentially bioactive N-alkyl-3-sulfonylindoles and N-alkyl-3-sulfanylindoles with various functional groups were successfully synthesized in moderate to good yields.

CuBr-promoted tandem cyclization/trifluoromethylation of 2-alkynylanilines: Efficient synthesis of 3-trifluoromethylindoles

A new efficient strategy for the synthesis of 3-trifluoromethyl-indoles was developed through tandem cyclization/ trifluoromethylation of 2-alkynylanilines and Umemoto’s reagent under effect of CuBr. The reaction features the use of cheap copper salt, mil