201738-24-1 Usage
Uses
Glycerophospho-N-Oleoyl Ethanolamine is a precursor to the cannabinoid compound OEA.
Biological Activity
glycerophospho-n-oleoyl ethanolamine is the precursor of oleoyl ethanolamide (oea). the fatty-acid ethanolamide, oleoylethanolamide (oea) is a naturally occurring lipid. oleoylethanolamide is an endogenous ppar-α agonist. oleoylethanolamide has been involved in modulating feeding and energy homeostasis by binding to peroxisome proliferator-activated receptor-alpha (ppar-α) [1]. ppar-α is a transcription factor and a major regulator of lipid metabolism in the liver. activation of ppar-α is mainly involved in fatty acid oxidation and expressed in liver, kidney, and skeletal muscle. through ligand binding, ppar-α promotes uptake, utilization, and catabolism of fatty acids [2].oea reduced food intake and lowered body-weight gain. subchronic oea treatment (5 mg/kg, i.p., once daily for two weeks) in zucker rats initiated transcription of ppar-α and other ppar-α target gene [1]. oea is an endogenous, potent agonist for pparα. oea activated pparα with an ec50 value of 120 nm in a transactivation assay [3]. in rodents, intraperitoneal administration of oea induced satiety and peripheral utilization of lipid substrate. acute oral administration induced satiety [4].
references
[1] fu j, oveisi f, gaetani s, et al. oleoylethanolamide, an endogenous ppar-α agonist, lowers body weight and hyperlipidemia in obese rats[j]. neuropharmacology, 2005, 48(8): 1147-1153.[2] schiffrin e l, amiri f, benkirane k, et al. peroxisome proliferator-activated receptors[j]. hypertension, 2003, 42(4): 664-668.[3] fu j, gaetani s, oveisi f, et al. oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor ppar-α[j]. nature, 2003, 425(6953): 90-93.[4] thabuis c, destaillats f, tissot‐favre d, et al. oleoyl‐ethanolamide (oea): a bioactive lipid derived from oleic acid and phosphatidylethanol‐amine[j]. lipid technology, 2007, 19(10): 225-227.
Check Digit Verification of cas no
The CAS Registry Mumber 201738-24-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,7,3 and 8 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 201738-24:
(8*2)+(7*0)+(6*1)+(5*7)+(4*3)+(3*8)+(2*2)+(1*4)=101
101 % 10 = 1
So 201738-24-1 is a valid CAS Registry Number.
