201741-15-3Relevant academic research and scientific papers
Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening
Disch, Jeremy S.,Duffy, Jennifer M.,Lee, Esther C. Y.,Gikunju, Diana,Chan, Betty,Levin, Benjamin,Monteiro, Michael I.,Talcott, Sarah A.,Lau, Anthony C.,Zhou, Fei,Kozhushnyan, Anton,Westlund, Neil E.,Mullins, Patrick B.,Yu, Yan,Von Rechenberg, Moritz,Zhang, Junyi,Arnautova, Yelena A.,Liu, Yanbin,Zhang, Ying,McRiner, Andrew J.,Keefe, Anthony D.,Kohlmann, Anna,Clark, Matthew A.,Cuozzo, John W.,Huguet, Christelle,Arora, Shilpi
, p. 5049 - 5066 (2021/05/06)
Bispecific degraders (PROTACs) of ERα are expected to be advantageous over current inhibitors of ERα signaling (aromatase inhibitors/SERMs/SERDs) used to treat ER+ breast cancer. Information from DNA-encoded chemical library (DECL) screening provides a me
Iron(III)triflate as a highly efficient, recyclable and green catalyst for the N-Boc protection of amines
Feng, Chengliang,Chu, Ningning,Zhang, Shuguang,Cai, Jin,Chen, Junqing,Hu, Huayou,Ji, Min
, p. 757 - 760 (2014/01/23)
Iron (III) triflate was used as an efficient catalyst for N-t-butoxycarbonylation of amines with di-t-butyl dicarbonate under solvent-free conditions at room temperature. Various aliphatic, aromatic, heterocyclic amines and aminols were protected as their corresponding mono-carbamates in excellent yields and short reaction times. Only two of the 23 monocarbamates were new. No competitive side reactions such as isocyanate, urea, nor N,N-di-Boc formation were observed. The reported method is mild and has the advantages of low cost, chemoselectivity and, because no solvent is used and the catalyst can be recycled, it is classifiable as a green procedure.
