201802-03-1Relevant academic research and scientific papers
Novel benzoxazole 2,4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships
Arakawa, Kenji,Inamasu, Masanori,Matsumoto, Mamoru,Okumura, Kunihito,Yasuda, Kosuke,Akatsuka, Hidenori,Kawanami, Saburo,Watanabe, Akishige,Homma, Koichi,Saiga, Yutaka,Ozeki, Masakatsu,Iijima, Ikuo
, p. 1984 - 1993 (2007/10/03)
A new series of benzoxazole 2,4-thiazolidinediones was synthesized and evaluated for hypoglycemic activity in genetically obese and diabetic yellow KK mice. 2-Arylmethyl- and 2-(heteroarylmethyl)benzoxazole derivatives showed far more potent activity than known 2,4-thiazolidinedione derivatives such as ciglitazone, troglitazone and pioglitazone. A facile synthesis of benzoxazole 2,4-thiazolidinediones was also established using aminophenol 2,4- thiazolidinedione (11) as a key intermediate. Details of synthesis and structure-activity relationships for this series are described.
