201809-20-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(5-Ethoxycarbonyl-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester is used as a building block in the synthesis of various bioactive compounds and drug molecules. Its unique structural elements, including the ethoxycarbonyl-pyridin-2-yl and piperazine moieties, contribute to the development of pharmaceuticals with enhanced biological activity and improved pharmacokinetic properties. The tert-butyl ester group also plays a crucial role in providing stability and solubility, which are essential for effective chemical synthesis and drug development processes.

Upstream product

• 49608-01-7 6-chloro-3-pyridinecarboxylic acid ethyl ester 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 201809-22-5 2-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}pyridin-5-carboxylic acid 
• 857284-20-9 tert-butyl 4-(5-(hydroxymethyl)pyridin-2-yl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase

The parasite Plasmodium vivax is the most widely distributed cause of recurring malaria. N-Myristoyltransferase (NMT), an enzyme that catalyses the covalent attachment of myristate to the N-terminal glycine of substrate proteins, has been described as a p

QUINOLINE DERIVATIVES AS SMO INHIBITORS

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

TROPANE COMPOUNDS

A compound according to Formula I or II: (I) or (II) wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.