201810-33-5

Upstream product

• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 99163-12-9 4-(pyridin-4-yl)benzaldehyde 
• 87199-17-5 4-formylphenylboronic acid, 
• 405939-28-8 (4-iodopyridin-2-yl)carbamic acid tert-butyl ester 

Downstream Products

• 622402-37-3 4-(3-phenyl-imidazo[1,2-a]pyridin-7-yl)-benzaldehyde 
• 622402-36-2 4-(3-iodo-imidazo[1,2-a]pyridin-7-yl)-benzaldehyde 
• 622402-35-1 4-imidazo[1,2-a]pyridin-7-yl-benzaldehyde 
• 622402-34-0 4-(2-aminopyridin-4-yl)benzaldehyde 

Relevant academic research and scientific papers

A multifunctional reagent designed for the site-selective amination of pyridines

We report the development of a multifunctional reagent for the direct conversion of pyridines to Boc-protected 2-aminopyridines with exquisite site selectivity and chemoselectivity. The novel reagent was prepared on 200-g scale in a single step, reacts in the title reaction under mild conditions without precautions toward air or moisture, and is tolerant of nearly all common functionality. Experimental and in situ spectroscopic monitoring techniques provide detailed insights and unexpected findings for the unique reaction mechanism.

Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR

3,7-Diarylsubstituted imidazopyridines were designed and developed as a new class of KDR kinase inhibitors. A variety of imidazopyridines were synthesized and potent inhibitors of KDR kinase activity were identified with good aqueous solubility.