201813-23-2Relevant academic research and scientific papers
Conjugate addition of amino acid side chains to dyes containing aikynone, alkynoic ester and alkynoic amide linker arms
Crisp, Geoffrey T.,Millan, Michael J.
, p. 649 - 666 (2007/10/03)
Derivatives of fluorescein, 7-hydroxycoumarin, Sudan 1 and dansyl chloride with linker arms containing a conjugated terminal alkyne have been prepared. The Michael addition of the sulfanyl group of protected cysteine, the hydroxyl group of protected serine and the ε-amino group of protected lysine to the conjugated alkyne gave the expected heterosubstituted vinyl products.
