201856-60-2Relevant articles and documents
Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
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, (2008/06/13)
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) STR1 with β-lac
Synthesis and Structure - Activity Relationships of New Antitumor Taxoids. Effects of Cyclohexyl Substitution at the C-3'-and/or C-2 of Taxotere (Docetaxel)
Ojima, Iwao,Duclos, Olivier,Zucco, Martine,Bissery, Marie-Christine,Combeau, C.,et al.
, p. 2602 - 2608 (2007/10/02)
Synthesis and cytotoxicity of the new analogs (11-13) of docetaxel possessing cyclohexyl groups instead of phenyl groups at the C-3' and/or C-2 benzoate positions are described. The C-2 cyclohexanecarboxylate analog of paclitaxel (15) is also synthesized