201858-64-2Relevant academic research and scientific papers
Synthesis of 1,2,4-triazole-fused heterocycles by tandem appel dehydration/thermal rearrangement methodology
Lee, Kee-Jung,Kim, Seong Heon,Kwon, Jong Hyuk
, p. 1461 - 1466 (1997)
The reaction of α-substituted benzophenone 1-acetamidoethylidenehydrazones 6b,c and 13a-d with a mixture of triphenylphosphine, carbon tetrachloride, and triethylamine in dichloromethane (Appel's condition) provides a general route to a variety of 1,2,4-triazole-fused heterocycles such as compounds 9-11, 16a-d, 17b-d, and 18 via the thermal rearrangement of the expected amino ketenimine intermediates.
