201936-47-2

Upstream product

• 201936-46-1 (Z)-(2S,9S,10R)-9-(tert-Butyl-dimethyl-silanyloxy)-10-(tert-butyl-diphenyl-silanyloxy)-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-methyl-undec-6-en-1-one 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 201936-44-9 Toluene-4-sulfonic acid (Z)-(7S,8R)-7-(tert-butyl-dimethyl-silanyloxy)-8-(tert-butyl-diphenyl-silanyloxy)-non-4-enyl ester 
• 201936-43-8 Toluene-4-sulfonic acid (Z)-(7S,8R)-8-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-non-4-enyl ester 
• 201936-41-6 (Z)-(2R,3S)-2-(tert-Butyl-diphenyl-silanyloxy)-9-triisopropylsilanyloxy-non-5-en-3-ol 
• 201936-40-5 (2R,3S)-2-(tert-Butyl-diphenyl-silanyloxy)-9-triisopropylsilanyloxy-non-5-yn-3-ol 
• 201936-45-0 C₃₁H₄₉IO₂Si₂ 
• 201936-42-7 (Z)-(7S,8R)-8-(tert-Butyl-diphenyl-silanyloxy)-non-4-ene-1,7-diol 
• 201936-38-1 tert-Butyl-((R)-(S)-1-oxiranyl-ethoxy)-diphenyl-silane 

Relevant academic research and scientific papers

Synthetic studies directed towards epothilone A: enantioselective synthesis of a C7-C15 carboxaldehyde segment

Enantioselective syntheses of a protected C7-C15 fragment of epothilone A is reported in ten manipulations in good overall yield. An alkynyl-aluminium induced opening of a chiral epoxide followed by recording of functionally furnished the iodide 18. Chain elongation with N-propionyl-1S-(-)-2,10-camphorsultam 19 afforded the elaborated acylsultam 20 which was reduced and reoxidized to furnish a protected chiral aldehyde 6 suitable for aldol condensation, representing the C7-C15 portion of epothilone A.