201995-25-7Relevant academic research and scientific papers
Synthesis and interfacial behavior of three homologous glycero neoglycolipids with various chain lengths
Boullanger,Sancho-Camborieux,Bouchu,Marron-Brignone,Morelis,Coulet
, p. 63 - 74 (1997)
Three neoglycolipids 1a-c derived from glycerol were synthezised and their molecular arrangements were studied at the air/water interface through Langmuir-Blodgett technique. The common structural features of these neoglycolipids are: a triethyleneglycol spacer at C-2 of glycerol, a GlcNAc hydrophilic head group at the end of the spacer, two saturated aliphatic chains at C-1 and C-3 of glycerol, linked by ether bonds. Compounds 1a-c differ only by the length of their lipid moieties. By increasing the hydrocarbon chain length from C11 to C16, a densely packed state was reached in the monolayer. The compression isotherms displayed an expanded state during the whole compression for compounds 1a and 1c bearing two C11 or one C11 and one C16 chains. Compound 1b bearing two C16 chains displayed a quite different interfacial behavior. The transfer of these monolayers onto a solid substrate can be obtained only with a trigger molecule, a phosphatidic acid.
